BPB Reports

Paper Details

BPB Reports
Vol. 6 No. 2 p.33-36 2023
Report
Cerium (IV) Oxide Nanoparticles Enhance Hepatotoxic and Nephrotoxic Effects of Paraquat, Cisplatin, or Acetaminophen in Mice
  • Katsuhiro Isoda (Graduate School of Pharmaceutical Sciences, Teikyo Heisei University / k.isoda@thu.ac.jp)
Yoshihiro Takahashi , Isao Ishida , Katsuhiro Isoda
Graduate School of Pharmaceutical Sciences, Teikyo Heisei University
Received: February 01, 2023;   Accepted: February 23, 2023;   Released: March 06, 2023
Keywords: nanoparticle, liver, kidney, drug interactions
Abstracts

Nanomaterials are central to nanotechnology and have many useful properties. Cerium(IV) oxide nanoparticles (nCeO) have catalytic and antioxidant activity, and hold promise in industrial and medical products. However, the potential biological hazards of nCeO have not been addressed. We therefore investigated the in vivo effects and drug interactions of nCeO. Tail vein administration of nCeO did not induce liver and kidney injury in mice but induced liver or kidney damage when co-administered with paraquat, cisplatin or acetaminophen. Therefore, our findings indicate that nCeO are potentially hepatotoxic and nephrotoxic due to drug interactions.