BPB Reports

Paper Details

BPB Reports
Vol. 4 No. 4 p.136-141 2021
Regular Article
Gastrointestinal Absorption of Ternatins, Polyacylated Anthocyanins Derived from Butterfly Pea (Clitoria ternatea L.) Petals in Rats
  • Takashi Ichiyanagi (Department of Ophthalmology, Niigata College of Medical Technologies / ichiyanagi@niigata-coll-mt.ac.jp)
Takashi Ichiyanagi 1) , Masayuki Nashimoto 2) , Norihiko Terahara 3)
1) Department of Ophthalmology, Niigata College of Medical Technologies , 2) Research Institute for Healthy Living, Niigata University of Pharmacy and Applied Life Sciences , 3) Department of Food Science and Technology, Faculty of Health & Nutrition, Minami Kyushu University
Received: July 28, 2021;   Accepted: August 19, 2021;   Released: September 02, 2021
Keywords: ternatin, anthocyanin, absorption, butterfly pea petal, side-chain, terminal structure

Ternatins, polyacylated anthocyanins that contain two or more aromatic acyl groups, are found in the petals of butterfly pea (Clitoria ternatea L.). We examined the gastrointestinal absorption of ternatins in rats after oral administration of the extract of the butterfly pea petals. Ingested ternatins were absorbed rapidly in the gastrointestinal tract in their original acylated forms. Nine ternatins were detected, together with preternatin A3, in rat blood plasma at 15 min after oral administration. After a single oral dose of 0.0527 mmol/kg ternatin, the maximum plasma concentration and area under the plasma concentration curve for total ternatin was 0.141 ± 0.035 μM and 16.398 ± 1.542 μM·min, respectively, during the 8-h period post-administration. The absorption of ternatins in blood plasma tended to negatively correlate with increasing order of molecular weight; however, ternatins carrying symmetrical substitution patterns and glucosyl terminals on the both side chains at the 3' and 5' positions of the aglycone were exceptionally bioavailable.