BPB Reports

Paper Details

BPB Reports
Vol. 4 No. 3 p.78-84 2021
Regular Article
Verification of MA-T Safety and Efficacy Against Pathogens Including SARS-CoV-2
  • Kiyoshi Konishi (Graduate School of Pharmaceutical Sciences, Osaka University / Institute for Open and Transdisciplinary Research Initiatives, Osaka University / konikiyo1954@gmail.com)
  • Yoshiharu Matsuura (Research Institute for Microbial Diseases, Osaka University / matsuura@biken.osaka-u.ac.jp)
Takekatsu Shibata 1) 2) 3) , Ryuta Urakawa 1) 4) , Chikako Ono 5) , Yukihiro Akeda 5) 6) , Takayoshi Sakai 7) , Shigeto Hamaguchi 6) , Kiyoto Takamori 2) , Tsuyoshi Inoue 1) 3) , Kazunori Tomono 6) , Kiyoshi Konishi 1) 3) , Yoshiharu Matsuura 5)
1) Graduate School of Pharmaceutical Sciences, Osaka University , 2) Acenet Inc. , 3) Institute for Open and Transdisciplinary Research Initiatives, Osaka University , 4) Department of Pharmacy, Osaka University Dental Hospital , 5) Research Institute for Microbial Diseases, Osaka University , 6) Graduate School of Medicine, Osaka University , 7) Graduate School of Dentistry, Osaka University
Received: March 17, 2021;   Accepted: May 11, 2021;   Released: May 26, 2021
Keywords: MA-T, SARS-CoV-2, disinfectant, chlorine dioxide, microorganism

Matching transformation system (MA-T) is an on-demand aqueous chlorine dioxide solution. It is a disinfectant developed to maximize the safety of chlorine dioxide radical in water and its effectiveness against various microorganisms. In this study, we examined the safety and effectiveness of MA-T for its use in various infectious disease countermeasures, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and consider if MA-T can be implemented in society. To validate the safety of MA-T, we conducted safety tests and efficacy tests in accordance with GLP-based reliability criteria. To evaluate the efficacy, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) confirmation tests against various bacteria, and virus inactivation test against various viruses including SARS-CoV-2 by TCID50 method were performed. The results of safety tests showed that MA-T was at least as safe as Japanese tap water. As a result of efficacy tests for microorganisms, MA-T was effective against many bacteria. Efficacy tests for virus showed that MA-T inactivates SARS-CoV-1, Middle East respiratory syndrome coronavirus (MERS-CoV), rotavirus A (RVA), hepatitis C virus (HCV), dengue virus (DENV), and hepatitis B virus (HBV). MA-T also inactivated 99.98% of SARS-CoV-2, which is equivalent to ethanol for disinfection. MA-T has proven to be a safe and effective disinfectant. MA-T is a next-generation disinfectant that has the potential to be safer and more effective than conventional chlorine disinfectants and other disinfectants. It also proved to be an effective disinfectant against SARS-CoV-2, which is currently causing pandemic all over the world.