BPB Reports

Paper Details

BPB Reports
Vol. 4 No. 1 p.47-54 2021
Regular Article
Methionine is a Key Regulator in the Onset of Atopic Dermatitis in NC/Nga Mice
  • Takayuki Koga (Daiichi University of Pharmacy / ta-koga@daiichi-cps.ac.jp)
Takayuki Koga 1) , Fuka Hirayama 1) , Tomomitsu Satoh 2) , Yuji Ishii 3) , Nobuhiro Kashige 2) , Makoto Hiromura 1) , Fumio Soeda 1) , Akihisa Toda 1)
1) Daiichi University of Pharmacy , 2) Faculty of Pharmaceutical Sciences, Fukuoka University , 3) Graduate School of Pharmaceutical Sciences, Kyushu University
Received: October 30, 2020;   Accepted: January 23, 2021;   Released: February 10, 2021
Keywords: atopic dermatitis, methionine, NC/Nga, metabolomics

Atopic dermatitis (AD) is a skin disorder that presents with itching and scratching and frequently progresses to a chronic state. AD often develops in patients with an individual or family history of allergic diseases. In addition, AD may develop in patients exposed to environmental stimuli such as air pollutants or dust. However, there can be differences in the magnitude of symptoms between patients even with the same genetic background or exposure to similar environmental conditions. NC/Nga mice have been used as a model for AD. They show AD-like symptoms in an age-dependent manner, even in the absence of AD-inducing agents. In addition, similar to humans, the magnitude of AD symptoms in this model varies between individual mice. However, the mechanisms underlying these differences are unclear. In addition, little is known about the relationship between AD skin symptoms and other organs and tissues. Here, we performed a metabolome analysis on sera from NC/Nga mice to identify factors potentially related to the severity of AD symptoms. The analysis showed a correlation between reduced serum methionine levels and increased severity of AD. In addition, treatment with excess methionine before the onset of AD symptoms suppressed the development of AD. In contrast, administration of methionine after the onset of AD symptoms did not. Importantly, cysteine and taurine, irreversible metabolites of methionine, did not suppress AD development. These results show that methionine, but not its metabolites, is a key factor in the onset, rather than the development of AD.