BPB Reports

Paper Details

BPB Reports
Vol. 3 No. 6 p.202-207 2020
Regular Article
A Randomized Placebo-controlled, Double-blind Study of Kosen-cha, a Polymerized Catechin-rich Green Tea, for Obesity in Pre-obese Japanese Subjects
  • Tatsuya Morimoto (Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka / Division of Translational Research, National Hospital Organization Kyoto Medical Center / Shizuoka General Hospital / morimoto@u-shizuoka-ken.ac.jp)
Yusuke Miyazaki 1) 2) 3) , Yasufumi Katanasaka 1) 2) 3) , Yusuke Tsutsui 1) , Yoichi Sunagawa 1) 2) 3) , Masafumi Funamoto 1) , Kana Shimizu 1) , Satoshi Shimizu 1) , Nurmila Sari 1) , Hajime Yamakage 4) , Noriko Satoh-Asahara 4) , Kazushige Toyama 5) , Mika Suzuki 6) , Atsushi Shimizu 7) , Hiromichi Wada 2) , Koji Hasegawa 1) 2) , Tatsuya Morimoto 1) 2) 3)
1) Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka , 2) Division of Translational Research, National Hospital Organization Kyoto Medical Center , 3) Shizuoka General Hospital , 4) Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, National Hospital Organization Kyoto Medical Center , 5) SBS Shizuoka Health Promotion Center , 6) Seirei Healthcare Support Center , 7) SUNDIA Co., Ltd.
Received: October 25, 2020;   Accepted: November 22, 2020;   Released: December 03, 2020
Keywords: Kosen-cha, polymerized catechin, obesity, liver enzymes
Abstracts

Green tea contains catechins, possessing anti-obesity and anti-oxidative effects, and has been consumed for hundreds of years. Our previous pilot study reported that Kosen-cha improves obesity and the parameters of metabolic syndromes in obese patients, however, the effect of Kosen-cha on obesity is still unclear in pre-obese subjects. The aim of this study was to investigate the effect of Kosen-cha on obesity and related clinical parameters including blood lipid and liver functions in a randomized placebo-controlled, double-blinded study. In total, 54 subjects with body mass index (BMI) of 25–30 were enrolled and randomized to receive either Kosen-cha or a placebo. The subjects drank Kosen-cha or the placebo thrice-daily for 12 weeks. Thereafter, we examined the effect of Kosen-cha on obesity (body weight, BMI, body fat, waist circumference, and visceral fat), lipid metabolism (triglyceride and high- and low-density lipoprotein cholesterol), and serum liver enzymes (aspartate aminotransferase, alanine aminotransferase (ALT), and γ-glutamyl transpeptidase). None of the subjects reported adverse effects from drinking Kosen-cha. Body weight, BMI, body fat, waist circumference, and visceral fat area remained unchanged in both groups. However, the change ratio of ALT significantly reduced between placebo and Kosen-cha groups after 12 weeks (Kosen-cha: −11.1 ± 32.7% vs. placebo: 8.46 ± 23.4%, p = 0.019). These results show that the consumption of Kosen-cha did not significantly improve obesity and may reduce liver enzyme levels in pre-obese Japanese subjects.