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BPB Reports
Vol. 7 No. 5 p.157-159 2024
Regular Article
Colistin Potentiates the Anti-bacterial Activity of 5-O-Mycaminosyltylonolide for Some Gram-Negative Bacteria
  • Yukihiro Asami (Graduate School of Infection Control Sciences, Kitasato University / Ōmura Satoshi Memorial Institute, Kitasato University / yasami@lisci.kitasato-u.ac.jp)
Aoi Kimishima 1) 2) , Hidehito Matsui 1) 2) , Yukiko Takarabe 2) , Masako Honsho 1) 2) , Paul Wasuwanich 3) , Sota Honma 1) 2) , Junsei Terai 1) , Hideaki Hanaki 1) 2) , Yukihiro Asami 1) 2)
1) Graduate School of Infection Control Sciences, Kitasato University , 2) Ōmura Satoshi Memorial Institute, Kitasato University , 3) University of Florida College of Medicine, USA
Received: July 08, 2024;   Accepted: September 03, 2024;   Released: September 25, 2024
Keywords: 5-O-mycaminosyltylonolide, Antimicrobial resistance, Gram-negative bacteria, Escherichia coli, Klebsiella pneumoniae
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Abstracts

We chose colistin as a new potentiator, which exhibited the relatively good potentiation activity of OMT against Escherichia coli and Klebsiella pneumoniae. This study uncovered new insight into an OMT based combination therapy.

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