Paper Details
BPB Reports
Vol. 6
No. 2
p.37-42
2023
Report
The Structure-Activity Relationship of MPBD and Dictyoquinone Analogs in Dictyostelium discoideum Cell Aggregation
- Yoshiaki Takaya (Graduate School of Pharmacy, Meijo University / Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga; Komplek Campus C, Indonesia / ytakaya@meijo-u.ac.jp)
Salma Zulqaida
1)
,
Tamao Saito
2)
,
Chihiro Ito
1)
,
Yoshiaki Takaya
1)
3)
1) Graduate School of Pharmacy, Meijo University , 2) Faculty of Science and Technology, Sophia University , 3) Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga; Komplek Campus C, Indonesia
1) Graduate School of Pharmacy, Meijo University , 2) Faculty of Science and Technology, Sophia University , 3) Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga; Komplek Campus C, Indonesia
Received: January 05, 2023;
Accepted: February 07, 2023;
Released: March 07, 2023
Keywords: slime mold, Dictyostelium discoideum, cell aggregation, differentiation factor, MPBD, dictyoquinone
Abstracts
4-Methyl-5-pentylbenzene-1,3-diol (MPBD) (1) and dictyoquinone (DQ or 2-hydroxy-5-methyl-6-pentyl-1,4-benzoquinone) (2) are two polyketides involved in the cell development of Dictyostelium discoideum. We synthesized several MPBD and DQ analogs and tested their ability to recover the cell aggregation delay in the stlA null strain. According to the findings, the alkyl side chain of both compounds facilitates their activity. The parent n-pentyl side chain is required for the cell aggregation.
