BPB Reports

Paper Details

BPB Reports
Vol. 5 No. 3 p.50-58 2022
Regular Article
Distribution, Metabolism, Excretion, and Lactational Transfer to Pups of Tetrabromobisphenol A and Its Metabolites in C57BL/6 Mice
  • Teruyuki Nakao (Faculty of Pharmaceutical Sciences, Setsunan University / nakao@pharm.setsunan.ac.jp)
Teruyuki Nakao , Hideki Kakutani , Tomohiro Yuzuriha , Souichi Ohta
Faculty of Pharmaceutical Sciences, Setsunan University
Received: December 24, 2021;   Accepted: May 20, 2022;   Released: June 07, 2022
Keywords: tetrabromobisphenol A, debrominated metabolites, lactational transfer, C57BL/6 mice

We characterized the absorption, distribution, metabolism, and excretion of tetrabromobisphenol A (TeBBPA) in C57BL/6 mice. After TeBBPA dosing, we monitored the mice and collected samples for 24 h. Most TeBBPA was excreted in the feces at 12 h. At 24 h, 71% of administered TeBBPA was found in the feces and TeBBPA-conjugates were detected at 17.8%. We also detected debrominated metabolites of TeBBPA, including tribromobisphenol A (TriBBPA), dibromobisphenol A (DiBBPA), and monobromobisphenol A (MoBBPA). TeBBPA, TriBBPA, 2,2′-DiBBPA and MoBBPA were detected in dam’s blood between 30 min and 1 h. Moreover, TriBBPA and 2,2′-DiBBPA were detected in milk at 30 min. The primary metabolites of TeBBPA were formed by conjugation, whereas debromination represented a minor metabolism pathway. Moreover, our findings demonstrated that the parent TeBBPA compound and its debrominated metabolites were distributed into the maternal milk of mice and transferred to the nursing pups following TeBBPA oral administration.