BPB Reports

Paper Details

BPB Reports
Vol. 4 No. 5 p.166-169 2021
Effect of Acylated Sugar Chain Terminals on the Intestinal Absorption of Large Molecular, Heavenly Blue Anthocyanin in Rats
  • Takashi Ichiyanagi (Department of Ophthalmology, Niigata College of Medical Technologies / ichiyanagi@niigata-coll-mt.ac.jp)
Takashi Ichiyanagi 1) , Masayuki Nashimoto 2) , Norihiko Terahara 3)
1) Department of Ophthalmology, Niigata College of Medical Technologies , 2) Research Institute for Healthy Living, Niigata University of Pharmacy and Applied Life Sciences , 3) Department of Food Science and Technology, Faculty of Health & Nutrition, Minami Kyushu University
Received: September 06, 2021;   Accepted: October 11, 2021;   Released: October 26, 2021
Keywords: heavenly blue anthocyanin, morning glory, peonidin 3-O-β-(6''-O-caffeoyl)-sophoroside-5-O-β-D-glucopyranoside, intestinal absorption, terminal structure

The gastrointestinal absorption of heavenly blue anthocyanin derived from morning glory (Pharbitis nil L.) was examined in rats. Ingested heavenly blue anthocyanin was directly absorbed from the gastrointestinal tract and detected in its original polyacylated form in rat blood plasma. The maximum plasma concentration and area under the plasma concentration curve during 8-h post-administration after a single oral dose of 0.0569 mmol/kg heavenly blue anthocyanin were 0.143 ± 0.023 μM and 23.30 ± 3.76 μM·min, respectively. Heavenly blue anthocyanin, which contains asymmetrical branched chains with glucosyl terminals, was absorbed at a similar level to that of total ternatin. By contrast, the plasma amount of heavenly blue anthocyanin was approximately 6-fold higher than that in a previous report of peonidin 3-O-β-(6''-O-caffeoyl)-sophoroside-5-O-β-D-glucopyranoside with an attached caffeoyl terminal on 6''-position.