BPB Reports

Paper Details

BPB Reports
Vol. 3 No. 3 p.106-112 2020
Regular Article
Brain Regions with Reduced Amounts of Mevalonate Pyrophosphate Decarboxylase Correspond to Sites of Strokes in Stroke-Prone Spontaneously Hypertensive Rats
  • Akihiro Michihara (Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University / mitihara@fukuyama-u.ac.jp)
Miyu Katayama , Hiroshi Matsuoka , Takahiro Hamashima , Akihiro Michihara
Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University
Received: December 07, 2019;   Accepted: December 28, 2019;   Released: June 11, 2020
Keywords: mevalonate pyrophosphate decarboxylase, cholesterol, brain, stroke-prone spontaneously hypertensive rats

Cholesterol deficiency is believed to result in fragile plasma membranes. It remains unclear whether a reduction in the amounts of both mevalonate pyrophosphate decarboxylase (MPD), which is involved in cholesterol biosynthesis, and cholesterol content occurs in the cerebrum and brain stem (diencephalon and midbrain) in or near the sites of strokes in stroke-prone spontaneously hypertensive rats (SHRSP). In this study, we investigated whether a reduction in both the amounts of MPD and cholesterol content corresponded to the sites of strokes in the SHRSP brain. The results obtained suggested that a reduction in the amount of MPD was involved in the decrease observed in cholesterol content, and was also important as a risk factor for stroke in SHRSP because the reductions in cholesterol content and MPD protein levels were associated with the sites of strokes. The mechanism responsible for reducing MPD protein levels in the brains of SHRSP differed with each region.