Fiber-rich foods are commonly consumed as part of dietary management or self-care by patients receiving long-term cardiometabolic pharmacotherapy. However, their physicochemical interactions with marketed pharmaceutical products under simulated intestinal conditions remain insufficiently characterized. This study evaluated the in vitro adsorption behavior of selected orally administered cardiometabolic drugs in artificial intestinal fluid in the presence of basil seeds or wheat bran. Commercially available products containing calcium channel blockers, beta-blockers, statins, or angiotensin II receptor blocker-related drugs were crushed and dispersed in artificial intestinal fluid, followed by the addition of basil seeds or wheat bran. Residual drug concentrations were determined by HPLC, and adsorption profiles were analyzed using pseudo-first-order and pseudo-second-order kinetic models. The reduction in residual drug concentration depended on both the drug and the food material. In the presence of wheat bran, amlodipine and carvedilol showed marked decreases in residual concentration, with residual rates of 32.9% and 16.6%, respectively, after 3 h. Nifedipine and olmesartan medoxomil also showed decreased residual concentrations, whereas bisoprolol, rosuvastatin, atorvastatin, and azilsartan showed only limited changes. The pseudo-second-order model showed better overall agreement with the adsorption profiles of the selected drugs. These findings provide a basis for further biopharmaceutical evaluation of physicochemical interactions between fiber-rich food materials and orally administered cardiometabolic drugs.